Determination of l-2-oxothiazolidine-4-carboxylic acid (Procysteine (cas 19771-63-2)®) in human plasma by high-performance liquid chromatography

Add time:09/05/2019    Source:sciencedirect.com

A new high-performance liquid chromatographic (HPLC) method has been developed for the determination of the cysteine prodrug, l-2-oxothiazolidine-4-carboxylic acid (Procysteine®), in human plasma. Samples were mixed with 5% metaphosphoric acid and the supernatants chromatographed using a reversed-phase analytical column. Procysteine was detected spectrophotometrically at 230 nm and quantitated by comparison with a standard curve of known amounts of Procysteine (20–1000 μM) in plasma. The coefficients of variation for 48.6 μM and 676 μM control pools were 6.5 and 4.0% respectively (n = 46). Deviations from the expected concentrations were less than 2%. The method has been utilized to evaluate the pharmacokinetics of a wide range of oral and intravenous doses.

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