Interaction of 5-bromowillardiine (cas 19772-78-2) with non-NMDA receptors expressed in Xenopus laevis oocytes injected with chick brain mRNA

Add time:09/02/2019    Source:sciencedirect.com

Excitatory amino acid (EAA) receptors were studied in Xenopus laevis oocytes microinjected with 1-day-old chick brain mRNA using a two-electrode voltage clamp technique. EAA agonists could be differentially characterised according to their current/voltage (IV) relationships; IV plots to kainate (KA) and domoate (Dom) inwardly rectified at positive membrane potentials whereas quisqualate (QA), α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) and l-glutamate (l-Glu) produced linear IV plots. Interesting, the non-NMDA (N-methyl-d-aspartate) agonist, 5-bromowillardiine (cas 19772-78-2) (BrW), displayed properties similar to KA and Dom. It is proposed that BrW acts as a KA-like agonist on chick EAA receptors expressed in Xenopus oocytes.

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