Solubility of an antiarrhythmic drug (Amiodarone hydrochloride (cas 19774-82-4)) in supercritical carbon dioxide: Experimental and modeling

Add time:09/02/2019    Source:sciencedirect.com

Solubility measurement of solid solute components in supercritical carbon dioxide (SC-CO2) provides essential information for forming pharmaceutical particles of smaller size with a desired size distribution, so as to achieve a better dissolution rate. In this study, for the first time, solubility of amiodarone hydrochloride (AMH) in SC-CO2 was determined using a static method at pressures and temperatures ranging within 12–30 MPa and 313.2–343.2 K, respectively. Under the applied conditions, molar solubilities were obtained in the range of 2.510 × 10−5 to 1.012 × 10−3. For correlating the drug solubility in SC-CO2, three of the most widely applied groups of models, namely semi-empirical density-based approaches, equations of state (EoSs), and regular solution models, were used. Statistical analysis of the results showed the superiority of the Peng-Robinson's model over other models for estimating the solubility of AMH based on experimental data.

We also recommend Trading Suppliers and Manufacturers of Amiodarone hydrochloride (cas 19774-82-4). Pls Click Website Link as below: cas 19774-82-4 suppliers

Prev:Gehinderte ligandbewegungen in übergangsmetallkomplexen XXXVI. Photoreaktivität von tricarbonyl-η5:1-(2-cyclopentadiendiyl)ethyl-wolfram gegenüber konjugierten dienen☆
Next:Utilization of ultrasonic-assisted RESOLV (US-RESOLV) with polymeric stabilizers for production of Amiodarone hydrochloride (cas 19774-82-4) nanoparticles: Optimization of the process parameters)