Novel 2-(2-(benzylthio)-1H-benzo[d]imidazol-1-yl)acetic acids: Discovery and hit-to-lead evolution of a selective CRTh2 receptor antagonist chemotype

Add time:09/02/2019    Source:sciencedirect.com

Hit-to-lead evolution of 2-(2-((2-(4-chlorophenoxy)ethyl)thio)-1H-benzo[d]imidazol-1-yl)acetic acid (1), discovered in a high-throughput screening campaign as a novel chemotype of CRTh2 receptor antagonist, is presented. SAR development as well as in vitro and in vivo DMPK properties of selected representatives of substituted 2-(2-(benzylthio)-1H-benzo[d]imidazol-1-yl)acetic acids are discussed.

We also recommend Trading Suppliers and Manufacturers of 2-([(4-CHLOROPHENYL)SULFONYL]AMINO)ACETIC ACID (cas 13029-72-6). Pls Click Website Link as below: cas 13029-72-6 suppliers

Prev:Research paperSynthesis and biological evaluation of pyridazinone derivatives as selective COX-2 inhibitors and potential anti-inflammatory agents
Next:Review articleArylsulfonamides and selectivity of matrix metalloproteinase-2: An overview)