Phosphodiesterase inhibitors. Part 6: Design, synthesis, and structure–activity relationships of PDE4-inhibitory pyrazolo[1,5-a]pyridines with anti-inflammatory activity

Add time:09/02/2019    Source:sciencedirect.com

We previously identified KCA-1490 [(−)-6-(7-methoxy-2-trifluoromethyl-pyrazolo[1,5-a]pyridin-4-yl)-5-methyl-4,5-dihydro-3-(2H)-pyridazinone], a dual PDE3/4 inhibitor. In the present study, we found highly potent selective PDE4 inhibitors derived from the structure of KCA-1490. Among them, N-(3,5-dichloropyridin-4-yl)-7-methoxy-2-(trifluoromethyl)pyrazolo[1,5-a]pyridine-4-carboxamide (2a) had good anti-inflammatory effects in an animal model.

We also recommend Trading Suppliers and Manufacturers of Pyrazolo[1,5-a]pyridin-3-amine, 2-methoxy- (cas 136548-56-6). Pls Click Website Link as below: cas 136548-56-6 suppliers

Prev:Research lettersNeurokinin B is hydrolysed by synaptic membranes and by endopeptidase-24.11 (‘enkephalinase’) but not by angiotensin converting enzyme
Next:Synthesis, anticancer assessment on human breast, liver and colon carcinoma cell lines and molecular modeling study using novel pyrazolo[4,3-c]pyridine derivatives)