Chapter 6 - Lamotrigine

Add time:09/03/2019    Source:sciencedirect.com

Lamotrigine (6-(2,3-Dichlorophenyl)-1,2,4-triazine-3,5-diamine), a phenyltriazine anticonvulsant, is a newer anti-epileptic drug. A profile of this drug substance is provided in this chapter and includes physical characteristics of Lamotrigine (e.g. Uv/Vis, IR, NMR and mass spectra). Details regarding the stability of Lamotrigine in the solid-state and solution-phase are presented and methods of analysis (compendial and literature) are summarized. Furthermore, an account of the pharmacokinetics (ADME) and synthesis of Lamotrigine are presented.

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