Design and synthesis of glycosidase inhibitor 5-amino-1,2,3,4-cyclohexanetetrol derivatives from (−)-vibo-quercitol☆

Add time:09/03/2019    Source:sciencedirect.com

In continuation of development of bioactive inositol derivatives, a 1-O-methyl derivative of 5-amino-5-deoxy-l-talo-quercitol was designed and synthesized as an analogue of the strong α-fucosidase inhibitor, 5a-carba-α-l-fucopyranosylamine, the methyl branch being replaced with methoxyl, and demonstrated to be a moderate α-fucosidase inhibitor. The present approach provides a possible route to apply alkyl ethers of aminodeoxyinositols as hexopyranose mimics of biological interest.

We also recommend Trading Suppliers and Manufacturers of 1,2,3,4-DI-O-ISOPROPYLIDENE-ALPHA-L-FUCOPYRANOSIDE (cas 136572-16-2). Pls Click Website Link as below: cas 136572-16-2 suppliers

Prev:Special CommunicationTransarterial Treatment of Colorectal Cancer Liver Metastases with Irinotecan-Loaded Drug-Eluting Beads: Technical Recommendations
Next:Computational study on the dimerization of INDOLOQUINOLIZINE (cas 136573-96-1)s)