Synthesis of 2,5-difunctionalised-3,3-DIMETHYLPIPERIDINE (cas 1193-12-0)s via ω-halogenated imines

Add time:07/15/2019    Source:sciencedirect.com

2,5-Difunctionalised-3,3-dimethylpiperidines were prepared by addition of nucleophiles to piperideinium salts, formed by electrophile-induced cyclisation of γ,δ-unsaturated imines with N-bromosuccinimide in alcoholic medium.

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Next:A multireceptorial binding reinvestigation on an extended class of σ ligands: N-[ω-(indan-1-yl and tetralin-1-yl)alkyl] derivatives of 3,3-DIMETHYLPIPERIDINE (cas 1193-12-0) reveal high affinities towards σ1 and EBP sites)