Design, synthesis and biological evaluation of paclitaxel-mimics possessing only the oxetane D-ring and side chain structures
-
Add time:09/04/2019 Source:sciencedirect.com
Two spiro paclitaxel-mimics consisting only of an oxetane D-ring and a C-13 side chain were designed and synthesized on the basis of analysis of structure–activity relationships (SAR) of paclitaxel. In vitro microtubule-stabilizing and antiproliferative assays indicated a moderate weaker activity of the mimics than paclitaxel, but which still represented the first example of simplified paclitaxel analogues with significant anti-tumor biological activity.
We also recommend Trading Suppliers and Manufacturers of PACLITAXEL SIDE CHAIN NO 1 (cas 133066-61-2). Pls Click Website Link as below: cas 133066-61-2 suppliers
Prev:A convenient one-pot approach to Paclitaxel (Taxol) side chain via 1,3-dipolar cycloaddition of carbonyl ylides and N-benzoylbenzyl imines
Next:Synthesis and biological evaluation of PSMA-targeting paclitaxel conjugates) - 【Back】【Close 】【Print】【Add to favorite 】
- Related Information
- The effect of surfactants modification on nanocrystalline cellulose for paclitaxel loading and release study09/24/2019
- Original ArticleCycloastragenol can negate constitutive STAT3 activation and promote paclitaxel-induced apoptosis in human gastric cancer cells09/10/2019
- Synthesis, isolation, stereostructure and cytotoxicity of paclitaxel analogs from cephalomannine09/09/2019
- Historical PerspectiveBasic principles of drug delivery systems – the case of paclitaxel09/08/2019
- Brain permeant and impermeant inhibitors of fatty-acid amide hydrolase suppress the development and maintenance of paclitaxel-induced neuropathic pain without producing tolerance or physical dependence in vivo and synergize with paclitaxel to reduce tumor cell line viability in vitro09/07/2019
- Topical PerspectivesToward an ab initio potential energy surface for paclitaxel: A C-13 isoserine side chain conformational study09/06/2019
- Synthesis and biological evaluation of PSMA-targeting paclitaxel conjugates09/05/2019
- A convenient one-pot approach to Paclitaxel (Taxol) side chain via 1,3-dipolar cycloaddition of carbonyl ylides and N-benzoylbenzyl imines09/03/2019
-
Health and Chemical more >