Synthesis of imprinted hydrogel microbeads by inverse Pickering emulsion to controlled release of adenosine 5′‑monophosphate

Add time:09/06/2019    Source:sciencedirect.com

Herein, we propose the synthesis of a microspherical imprinted hydrogel meant for the controlled release of a nucleotide, adenosine 5′-monophosphate (5′-AMP). Indeed, molecularly imprinted polymers-based (MIPs) materials possess remarkable selective molecular recognition ability that mimicks biological systems. MIPs have been used in numerous applications and hold great promise for the vectorization and/or controlled release of therapeutics and cosmetics. But, the conception of imprinted hydrogels-based drug delivery systems that are able to release polar bioactive compounds is explored weakly. Herein, the synthesis of imprinted hydrogel microbeads by inverse Pickering emulsion is detailed. Microspheres showed a large 5′-AMP loading capacity, around 300 mg·g−1, and a high binding capacity comparatively to the non-imprinted counterpart. The MIP had a thermo-responsive release behavior providing sustained release of adenosine 5′-monophosphate in an aqueous buffer simulating both human skin pH and temperature.

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