Automated synthesis of [18F](2S,4R)-4-fluoroglutamine on a GE TRACERlab™ FX-N Pro module

Add time:09/03/2019    Source:sciencedirect.com

Glutamine (Gln) and its analogues may serve as imaging agents for tumor diagnosis using positron emission tomography (PET), especially for tumors with negative [18F]FDG scan. We report the first automated synthesis of [18F](2S,4R)-4-fluoroglutamine ([18F]FGln) on a GE TRACERlab™ FX-N Pro module. [18F]FGln was obtained in 80±3 min with a radiochemical yield of 21±3% (n=5, uncorrected). The radiochemical purity was >98%, and optical purity 90±5%. The synthesis is highly reproducible with good chemical purity, radiochemical yield, and is suitable for translation to cGMP production.

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