Synthesis and biological evaluation of new taxoids derived from 2-deacetoxytaxinine J

Add time:09/04/2019    Source:sciencedirect.com

A small library of 2-deacetoxytaxinine J (DAT-J) 1 derivatives was synthesised and tested in vitro for their reversal activity in human mammary carcinoma MDR cell line MCF7-R. One of the new taxoids showed to be active at 0.1 μM when tested in combination with paclitaxel.

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