Mutagenicity to Salmonella of the mono methylamino and N-cyanoethyl analogues of 4-dimethylaminoazobenzene (DAB) and 6-DIMETHYLAMINOPHENYLAZOBENZTHIAZOLE (cas 18463-90-6) (6BT)

Add time:09/03/2019    Source:sciencedirect.com

Replacement of one of the methyl groups of the carcinogens 4-dimethylaminoazobenzene (DAB) and 6-DIMETHYLAMINOPHENYLAZOBENZTHIAZOLE (cas 18463-90-6) (6BT) with a cyanoethyl (−CH2CH2CN) substituent dramatically increases their mutagenic potency to Salmonella (strain TA98). The corresponding monomethylamino derivatives (−NHCH3) are more mutagenic than the parent dimethylamino [−N(CH3)2] compounds, but substantially less mutagenic than the cyanoethyl derivatives. All of these mutagenic activities are liver-S-9-dependent. The very similar dose response curves observed for the two cyanoethyl compounds argues for the formation of a common electrophilic intermediate from each.

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