A convenient microwave-assisted desulfitative dimethylamination of the 2(1H)-pyrazinone scaffold using N,N-dimethylformamide

Add time:07/14/2019    Source:sciencedirect.com

A convenient microwave-assisted methodology is developed for the generation of 5-chloro-3-(dimethylamino)pyrazin-2(1H)-ones. The method entails a chemoselective desulfitative removal of a phenylthioether bond upon DMF/H2O treatment in the presence of sodium carbonate, yielding the desired compounds in 73–96%.

We also recommend Trading Suppliers and Manufacturers of 4-[2-(phenylsulfanyl)benzyl]morpholine (2E)-but-2-enedioate (cas 127876-77-1). Pls Click Website Link as below: cas 127876-77-1 suppliers

Prev:Aspirin-inspired organometallic compounds: Structural characterization and cytotoxicity
Next:Natural β-carboline alkaloids regulate the PI3K/Akt/mTOR pathway and induce autophagy in insect Sf9 cells)