An expedient stereoselective synthesis of (E)-α,β-unsaturated esters and thioesters using FeCl3·6H2O

Add time:09/05/2019    Source:sciencedirect.com

Facile and convenient synthesis of α,β-unsaturated esters and thioesters from alkylidene derivatives of Meldrum’s Acid is described. This method uses catalytic amount of FeCl3·6H2O (0.001–0.005 equiv) with alcohols/thiols (1 equiv) in dry CH3NO2 followed by catalytic amount of piperidine. A variety of α,β-unsaturated esters and thioesters have been synthesized with high E-stereoselectivity in good to excellent yields. The application of this methodology is demonstrated by gram scale synthesis of octinoxate, a sunscreen agent, and other p-methoxycinnamate esters.

We also recommend Trading Suppliers and Manufacturers of 2-(2-Methoxybenzylidene)-3-oxobutyric acid ethyl ester (cas 15725-24-3). Pls Click Website Link as below: cas 15725-24-3 suppliers

Prev:Synthesis, biological activities, and molecular docking studies of 2-mercaptobenzimidazole based derivatives
Next:Synthesis and biological evaluation of new flavonoid fatty acid esters with anti-adipogenic and enhancing glucose consumption activities)