Selective mono-fluorination of diols via a cyclic acetal of N,N-diethyl-4-methoxybenzamide

Add time:09/07/2019    Source:sciencedirect.com

Selective mono-fluorination of 1,2- and 1,3-diols was achieved using N,N-diethyl-4-methoxybenzamide diethyl acetal and Et3N-3HF. The reaction proceeds through a cyclic acetal of the benzamide, and only one hydroxy group was fluorinated and another one was acylated.

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