An improved method for the large scale preparation of α,α′-trehalose-6-phosphate

Add time:09/03/2019    Source:sciencedirect.com

An improved method was developed for the efficient, large-scale synthesis of α,α′-trehalose-6-phosphate starting with α,α′-trehalose. In the sequence, octa-trimethylsilylation of α,α′-trehalose is followed by selective removal of the 6-O-trimethylsilyl protecting group. Reaction of the mono-alcohol with (PhO)2POCl is then followed by simultaneous hydrogenolysis and per-desilylation to generate α,α′-trehalose-6-phosphate, free of contamination by inorganic phosphate.

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