Short communicationRh-catalyzed selective synthesis of 1,5-dimethylhexahydro-1H-inden-4(2H)-one via hydroformylation of (R)-carvone

Add time:09/03/2019    Source:sciencedirect.com

This work reports domino hydroformylation, hydrogenation and intramolecular keto-aldol condensation reactions for the selective synthesis of 1,5-dimethylhexahydro-1H-inden-4(2H)-one obtained from (R)-carvone and dihydrocarvone under homogeneous hydroformylation condition. The synthesis of the desired product was achieved by using conventional rhodium/1,3-bis(diphenylphosphino)propane (Rh/dppp) catalyst and PPTS (pyridinium p-toluenesulfonate) as an acidic co-catalyst. The reaction conditions were optimized with respect to various reaction parameters like time, temperature, synthesis gas (CO/H2) pressure, solvents, catalyst and co-catalyst loading. The experimental results showed that less planner carbon backbone in dihydrocarvone increases the steric hindrance around the reaction site and responsible for the reactivity difference between (R)-carvone and dihydrocarvone.

We also recommend Trading Suppliers and Manufacturers of 4(1H)-Pteridinone,2-amino-5,6,7,8-tetrahydro-6-methyl-,(R)-(9CI) (cas 136693-01-1). Pls Click Website Link as below: cas 136693-01-1 suppliers

Prev:Original articleInvestigation of Ugi-4CC derived 1H-tetrazol-5-yl-(aryl) methyl piperazinyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid: Synthesis, Biology and 3D-QSAR analysis
Next:Research paperSynthesis, characterisation and electrochemistry of eight Fe coordination compounds containing substituted 2-(1-(4-R-phenyl-1H-1,2,3-triazol-4-yl)pyridine ligands, R = CH3, OCH3, COOH, F, Cl, CN, H and CF3)