Research ArticlesOleate salt formation and mesomorphic behavior in the propranolol/oleic acid binary system

Add time:09/09/2019    Source:sciencedirect.com

Thermal analysis of propranolol/oleic acid mixtures prepared by solvent evaporation enabled construction of the binary system phase diagram. This allowed both physical and chemical interactions to be identified, including complex formation at the equimolar composition. An incongruent melting complex with a characteristic reaction point was identified in excess oleic acid compositions, a common property of fatty acid/fatty acid salt binary systems. The equimolar complex was confirmed to be propranolol oleate using infrared spectroscopy. Wide-angle X-ray powder diffrac-tometry demonstrated that propranolol oleate possessed long-range positional order (∼25 Å d spacing) accompanied by a degree of disorder over shorter d spacings. Such a pattern suggested mesophase formation, explaining the unctuous nature of propranolol oleate at room temperature. Accurate measurement of the long-range d spacing was achieved using small-angle X-ray scattering, permitting differentiation of the three different phases identified (phase I: 25.4 Å, phase II: 24.6 Å, phase III: 25.4–25.5 Å). The implications of drug fatty acid salt formation and also mesomorphism in pharmaceutical systems are discussed.

We also recommend Trading Suppliers and Manufacturers of propranolol laurate (cas 138656-55-0). Pls Click Website Link as below: cas 138656-55-0 suppliers

Prev:Research paperDemonstration of the importance of biphasic oleic acid delivery for enhancing the bioavailability of propranolol in healthy volunteers
Next:ArticlesMechanism for the Enhancement Effect of Fatty Acids on the Percutaneous Absorption of Propranolol)