Effect of enrofloxacin and Roxarsone (cas 121-19-7) on CYP450s in pig

Add time:09/08/2019    Source:sciencedirect.com

Enrofloxacin (ENR) and Roxarsone (cas 121-19-7) (ROX) have been widely used in animal breeding. In this study, the daily clinical dosage of ENR and daily additive amount of ROX were administrated to Bama pigs. After 5 days, the activity and protein expression of three important enzymes in the cytochrome P450 family were measured in the porcine liver. CYP1A2 was induced by both ENR and ROX independently. CYP2E1 and CYP3A4 were inhibited by ENR, but not affected by ROX. The combined administration of ENR and ROX were antagonistic to CYP1A2 and CYP2E1, but not to CYP3A4. Drug-drug interactions should be considered during the administration of ENR, ROX and for their co-administration with other drugs to minimize adverse reactions.

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