Determination of the absolute configuration of chiral aryl–alkyl carbinols using organophosphorus diamine derivatizing agents by 31P NMR spectroscopy

Add time:07/14/2019    Source:sciencedirect.com

The prediction of the absolute configuration of chiral alcohols, namely phenylcarbinols, from the 31P NMR spectra of the diastereoisomers obtained with organophosphorus diamino-derivatizing agents is presented. A simplified model based on NMR and crystallographic data is given, which associates the spatial location of the substituents of the stereogenic alcohol centre with the sign of the Δδ(R−S) (Δδ(R−S) representing the chemical shift difference between two diastereoisomers of the CDAs and the chiral secondary alcohol).

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