Facile synthesis of 1-substituted 5-trifluoromethylimidazole-4-carboxylates

Add time:07/14/2019    Source:sciencedirect.com

Base-induced cycloaddition of ethyl isocyanoacetates to trifluoroacetimidoyl chlorides gives ethyl 5-trifluoromethylimidazole-4-carboxylates with high regioselectivity.

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