3-Substituted Quinolines as RORγt Inverse Agonists

Add time:09/07/2019    Source:sciencedirect.com

We have previously reported the syntheses of a series of 3,6-disubstituted quinolines as modulators of the retinoic acid receptor-related orphan receptor gamma t (RORγt). These molecules are potent binders but are high molecular weight and they exhibited poor solubility at pH 2 and pH 7. This manuscript details our efforts at improving physical chemical properties for this series of compounds by increasing the diversity at the 3-position (i.e. introducing heteroatoms and lowering the molecular weight). These efforts have led to molecules which are potent binders with improved solubility.

We also recommend Trading Suppliers and Manufacturers of 4-CHLORO-2-METHYL-7-(TRIFLUOROMETHYL)QUINOLINE (cas 18529-09-4). Pls Click Website Link as below: cas 18529-09-4 suppliers

Prev:Design, Synthesis and Anticancer Evaluation of New Substituted Thiophene-Quinoline Derivatives
Next:C5-selective trifluoromethylation of 8-amino quinolines via photoredox catalysis)