Direct chemical glycosylation with pentenyl- and thioglycoside donors of N-acetylglucosamine
-
Add time:09/10/2019 Source:sciencedirect.com
The use of pentenyl and thiophenyl glycosides of N-acetylglucosamine (GlcNAc) as glycosyl donors for the direct preparation of O-glycosides of GlcNAc promoted by N-iodosuccinimide (NIS) and metal triflates in dichloromethane has been investigated. Both glycosyl acceptors 1-octanol and (−)-menthol resulted in good glycosylation yields for both types of donors with pentenyl glycosides being somewhat superior in terms of yield. Carbohydrate-based acceptors were reacted with a benzylated GlcNAc-pentenyl donor but only provided disaccharides in poor to moderate yields. The results show that a variety of metal triflates are capable of acting as an activator for both NIS and the intermediate oxazoline.
We also recommend Trading Suppliers and Manufacturers of N-ACETYLGLUCOSAMINE 6-SULFATE SODIUM SALT (cas 108321-79-5). Pls Click Website Link as below: cas 108321-79-5 suppliers
Prev:The enzymic synthesis of β-[32P]UDP-N-acetylglucosamine
Next:Structural Analysis of N-acetylglucosamine-6-phosphate Deacetylase Apoenzyme from Escherichia coli) - 【Back】【Close 】【Print】【Add to favorite 】
- Related Information
- Terminal N-Acetylglucosamine Containing Proteins and N-Acetylglucosamine Binding Proteins from Organelles and Membranes of Developing Pea (Pisum sativum L.) Cotyledons09/27/2019
- RETRACTED: Modification of TAK1 by O-linked N-acetylglucosamine facilitates TAK1 activation and promotes M1 macrophage polarization09/26/2019
- Engineering a new pathway for N-acetylglucosamine production: Coupling a catabolic enzyme, glucosamine-6-phosphate deaminase, with a biosynthetic enzyme, glucosamine-6-phosphate N-acetyltransferase09/25/2019
- Structural Analysis of N-acetylglucosamine-6-phosphate Deacetylase Apoenzyme from Escherichia coli09/24/2019
- The enzymic synthesis of β-[32P]UDP-N-acetylglucosamine09/09/2019
- Increased N-acetyl-β-glucosaminidase activity in primary breast carcinomas corresponds to a decrease in N-acetylglucosamine containing proteins09/08/2019
- Metabolic engineering of Escherichia coli for industrial production of glucosamine and N-acetylglucosamine09/07/2019
- Novel biologically active series of N-acetylglucosamine derivatives for the suppressive activities on GAG release09/06/2019
- Production of chitinase from Escherichia fergusonii, chitosanase from Chryseobacterium indologenes, Comamonas koreensis and its application in N-acetylglucosamine production09/05/2019
