Efficient synthesis of eudistomin U and evaluation of its cytotoxicity
-
Add time:09/07/2019 Source:sciencedirect.com
Eudistomin U is a member of a subclass of naturally occurring indole alkaloids known as β-carbolines. These molecules are reported to have diverse biological activity and high binding affinity to DNA, which make them attractive targets for total synthesis. We describe an efficient, five-step synthesis of eudistomin U by employing two key reactions: a Bischler–Napieralski cyclization and a Suzuki cross coupling. We also describe the cytotoxicity of eudistomin U against various cancer cell lines and human pathogens, in which we observed potent antibacterial activity against Gram-positive bacteria.
We also recommend Trading Suppliers and Manufacturers of eudistomin T (cas 108335-05-3). Pls Click Website Link as below: cas 108335-05-3 suppliers
Prev:DNA-binding studies of the natural β-carboline eudistomin U
Next:The chemistry of vicinal tricarbonyl compounds. Short syntheses of eudistomins T, I and M) - 【Back】【Close 】【Print】【Add to favorite 】
- Related Information
- Biosynthetic studies of eudistomin H in the tunicate Eudistoma olivaceum09/27/2019
- Antimalarial and antitubercular nostocarboline and eudistomin derivatives: Synthesis, in vitro and in vivo biological evaluation09/26/2019
- Photochemistry of the alkaloids eudistomin N (6-bromo-nor-harmane) and eudistomin O (8-bromo-nor-harmane) and other bromo-β-carbolines09/25/2019
- Iminophosphorane-mediated synthesis of 1-acyl-β-carbolines: A new access to the alkaloids eudistomin T (cas 108335-05-3), S and xestomanzamine A of marine origin09/24/2019
- Synthesis of eudistomin D analogues and its effects on adenosine receptors09/10/2019
- Short, efficient syntheses of the antibiotic eudistomins I and T09/09/2019
- The chemistry of vicinal tricarbonyl compounds. Short syntheses of eudistomins T, I and M09/08/2019
- DNA-binding studies of the natural β-carboline eudistomin U09/06/2019
- Research paperComputer-aided drug discovery: Novel 3,9-disubstituted eudistomin U derivatives as potent antibacterial agents09/05/2019
