Effects of l-threo-DOPS, an l-noradrenaline precursor, on locus coeruleus-originating neurons in spinal trigeminal nucleus

Add time:09/07/2019    Source:sciencedirect.com

Electrophysiological studies using reserpinized cats were performed to examine the effects of l-threo-3,4-dihydroxyphenylserine(l-threo-DOPS) on the noradrenergic pathway from the locus coeruleus (LC)_to the spinal trigeminal nucleus (STN). The spike generation of STN relay neurons induced by trigeminal nerve stimulation was not affected by LC conditioning stimulation nor iontophoretic application of l-threo-DOPS. After intraventricular administrayion of l-threo-DOPS, the inhibition of the spike generation was seen with LC conditioning stimulation and blocked by iontophoretically applied sotalol, suggesting thatl-noradrenaline converted from l-threo-DOPS inhibits transmission of STN relay neurons.

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