CommunicationAsymmetric 1,3-dipolar cycloaddition: Synthesis of N-protected (4S)-4-hydroxy L-glutamic acid diester
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Add time:09/26/2019 Source:sciencedirect.com
An asymmetric synthesis of N-protected (4S)-4-hydroxy L-glutamic acid diester is described. The key feature of the synthesis is the asymmetric 1,3-dipolar cycloadition of nitrone 4 with 5, which provides stereoselectively the isoxazolidine with the correct stereochemistry suitable for the synthesis of N-protected (4S)-4-hydroxy L-glutamic acid diester 1.
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