Synthetic approaches toward glidobamine, the core structure of the Glidobactin A (cas 108351-50-4)ntibiotics

Add time:09/09/2019    Source:sciencedirect.com

Peptide synthesis method was first employed to synthesize glidobamine, the core structure of the glidobactin antibiotics (2), but in a model study all attempts failed to cyclize the linear precursor 10. Then a NN bond cleavage method was developed to construct the ring skeleton of glidobamine (2). A new synthetic plan was designed according to this strategy and the two requisite building blocks 19 and 32 were synthesized. Therefore a route to 2 has been laid. In the synthesis of the right-hand side building block (Scheme 6) a trouble of competitive lactonization was encountered. This problem was finally solved by using a strong eletron-withdrawing group (31).

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