Asymmetric cyclopropanation of ketene silyl acetal with allylic acetate catalyzed by a palladium complex

Add time:07/15/2019    Source:sciencedirect.com

The first asymmetric cyclopropanation of ketene silyl acetal with allylic acetate was achieved. New chiral oxazolidinylpyrazole ligands and their η3-allylpalladium complexes were synthesized. Reaction of cinnamyl acetate with ketene silyl acetal of ethyl isobutylate in the presence of a palladium complex gave a phenyl cyclopropane derivative in 20∼ 54%ee.

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