Short communicationDifferential binding in vitro to glucocorticoid receptors of deflazacort and prednisolone

Add time:09/05/2019    Source:sciencedirect.com

Deflazacort, a new steroidal anti-inflammatory agent, has remarkable glucocorticoid activity in both animals, and humans. Its biologically active form, 21-desacetyl deflazacort, displaces [3H]dexamethasone from its cytosol receptor sites in rat kidney, thymus and liver in vitro. Although less active than prednisolone in its binding to glucocorticoid receptors, deflazacort ‘stabilizes’ the resulting steroid-receptor complex more effectively than the former in the kidney and thymus but not in the liver. This property might explain the greater activity of deflazacort than of prednisolone in the rat.

We also recommend Trading Suppliers and Manufacturers of 21-DESACETYL DEFLAZACORT (cas 13649-57-5). Pls Click Website Link as below: cas 13649-57-5 suppliers

Prev:The antidepressant-like effects of the 3β-hydroxysteroid dehydrogenase inhibitor Trilostane (cas 13647-35-3) in mice is related to changes in neuroactive steroid and monoamine levels
Next:Binding of the anti-inflammatory steroid deflazacort to glucocorticoid receptors in brain and peripheral tissues. In vivo and in vitro studies)