Labeling of Alprenolol (cas 13655-52-2) with fluorescent aryl iodide as a reagent based on Mizoroki–Heck coupling reaction
-
Add time:09/06/2019 Source:sciencedirect.com
A novel fluorescent labeling method for Alprenolol (cas 13655-52-2) was developed based on Mizoroki–Heck coupling reaction. We designed and synthesized fluorescent aryl iodide, 4-(4,5-diphenyl-1H-imidazol-2-yl)iodobenzene (DIBI) as a labeling reagent. DIBI has a lophine skeleton carrying an iodide atom acting as fluorophore and reactive center, respectively. In order to evaluate the usefulness of DIBI, a high-performance liquid chromatography (HPLC) with fluorescence detection method was developed for the determination of alprenolol as a model compound of terminal double bond. The fluorescent labeling of alprenolol with DIBI was achieved in the presence of palladium acetate as a catalyst, and the labeled alprenolol was detected fluorometrically. In addition, it was found that the fluorescence of DIBI derivative increased and red shifted when compared with that of DIBI. Furthermore, the proposed method could be applied to determine the alprenolol concentration in rat plasma after administration of alprenolol without interferences from biological components. The detection limit (S/N = 3) for alprenolol in rat plasma was 0.74 ng/mL (30 fmol on column).
We also recommend Trading Suppliers and Manufacturers of Alprenolol (cas 13655-52-2). Pls Click Website Link as below: cas 13655-52-2 suppliers
Prev:Quantification of Alprenolol (cas 13655-52-2) and propranolol in human plasma using a two-dimensional liquid chromatography (2D-LC)
Next:Enantioselective biodegradation of pharmaceuticals, Alprenolol (cas 13655-52-2) and propranolol, by an activated sludge inoculum) - 【Back】【Close 】【Print】【Add to favorite 】
- Related Information
- Combined pharmacokinetic and pharmacodynamic studies on Alprenolol (cas 13655-52-2) and 4-hydroxy-Alprenolol (cas 13655-52-2) in man09/27/2019
- Microcalorimetric studies on the complex formation between cellobiohydrolase I (CBH I) from Trichoderma reesei and the (R)- and (S)-enantiomers of the β-receptor blocking agent Alprenolol (cas 13655-52-2)09/26/2019
- Gel formulations containing catanionic vesicles composed of Alprenolol (cas 13655-52-2) and SDS: Effects of drug release and skin penetration on aggregate structure09/25/2019
- Regular paperAnalysis of the vasodilator action of Alprenolol (cas 13655-52-2)09/24/2019
- Nasal absorption of Alprenolol (cas 13655-52-2) and metoprolol09/10/2019
- Enantioselective determination of Alprenolol (cas 13655-52-2) in human plasma by liquid chromatography with tandem mass spectrometry using cellobiohydrolase chiral stationary phases09/09/2019
- Electrophoretic behavior of Alprenolol (cas 13655-52-2) in mixed solvent electrolyte systems09/08/2019
- Enantioselective biodegradation of pharmaceuticals, Alprenolol (cas 13655-52-2) and propranolol, by an activated sludge inoculum09/07/2019
- Quantification of Alprenolol (cas 13655-52-2) and propranolol in human plasma using a two-dimensional liquid chromatography (2D-LC)09/05/2019