(2R,3R)-dicyclohexyl tartrate (cas 15785-59-8) as a chiral mobile phase additive

Add time:09/05/2019    Source:sciencedirect.com

The enantiomers of acids, esters and amino alcohols of moderate hydrophobicity containing two hydrogen bonding functions were separated in underivatized form using (2R,3R)-dicyclohexyl tartrate (DCHT) in phosphate buffer (pH 3) as mobile phase and porous graphitic carbon (Hypercarb) as stationary phase. The retention of the solutes can be controlled by the concentration of DCHT in the mobile phase without affecting the enantioselectivity. A low pH in the mobile phase gave optimum enantioselectivity for both acidic and basic solutes. DCHT, which is water soluble up to 0.5 mM, has a high affinity for the graphitic carbon phase when using phosphate buffer as the mobile phase. It seems to be adsorbed on the support as a monolayer as changes in the concentration of the mobile phase have only a minor influence on the amount adsorbed (0.14 mmol/g support). Addition of acetonitrile to the mobile phase in higher amounts decreased the amount of DCHT adsorbed on the carbon support and also decreased the retention and the stereoselectivity.

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