Discovery, SAR and X-ray structure of 1H-Benzimidazole-5-carboxylic acid (cas 15788-16-6) cyclohexyl-methyl-amides as inhibitors of inducible T-cell kinase (Itk)

Add time:09/07/2019    Source:sciencedirect.com

A series of novel potent benzimidazole based inhibitors of interleukin-2 T-cell kinase (Itk) were prepared. In this report, we discuss the structure–activity relationship (SAR), selectivity, and cell-based activity for the series. We also discuss the SAR associated with an X-ray structure of one of the small-molecule inhibitors bound to ITK.

We also recommend Trading Suppliers and Manufacturers of 1H-Benzimidazole-5-carboxylic acid (cas 15788-16-6). Pls Click Website Link as below: cas 15788-16-6 suppliers

Prev:Synthesis and biological evaluation of novel 1-(4-methoxyphenethyl)-1H-Benzimidazole-5-carboxylic acid (cas 15788-16-6) derivatives and their precursors as antileukemic agents
Next:Quinolizidinyl derivatives of 2,3-dihydro-2-oxo-1H-benzimidazole-1-carboxylic acid and 1-homolupinanoyl benzimidazolones as ligands for 5-HT3 and 5-HT4 receptors☆)