A PASE-based approach towards 12-(1H-1,2,3-triazol-1-yl)-indolo[2,1-a]isoquinolines via the reaction of 3-(isoquinolin-1-yl)-1,2,4-triazines with benzyne

Add time:09/06/2019    Source:sciencedirect.com

12-(1H-1,2,3-Triazol-1-yl)indolo[2,1-a]isoquinolines are prepared in 51–56% yields using a PASE (pot, atom, step, economic)-based approach, namely, by the reaction between available 5-R-6-Ar-3-(isoquinolin-1-yl)-1,2,4-triazines and in situ generated benzyne. A mechanism comprising domino-transformation was suggested, and the structure of one key product was confirmed by a single crystal X-ray diffraction analysis.

We also recommend Trading Suppliers and Manufacturers of 1-(isoquinolin-1-yl)hydrazine (cas 15793-94-9). Pls Click Website Link as below: cas 15793-94-9 suppliers

Prev:Reaction of hydrazinoquinolines with trifluoromethyl-β-diketones: structural and mechanistic studies
Next:Research paperApolipoprotein E genetic polymorphism influence the susceptibility to nephropathy in type 2 diabetes patients)