ArticlesPharmaceutical Studies with Thiamine mononitrate (cas 18601-90-6)

Add time:09/09/2019    Source:sciencedirect.com

Thiamine mononitrate, the salt formed from one mole of thiamine base and one mole of nitric acid, occurs as an anhydrous crystalline solid of low hygroscopicity, differing in this respect from thiamine hydrochloride. The stability of thiamine mononitrate was investigated in sterile solutions, compressed tablets, multivitamin capsules and dry-filled capsules. Assay data are given to show that thiamine mononitrate is more stable than thiamine hydrochloride in these preparations. The use of thiamine mononitrate in B complex capsules eliminated the need for an acidic stabilizer, the presence of which accelerated the decomposition of the pantothenic acid component.

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