Synthesis of novel 3,4,6-trisubstituted quinolines enabled by a Gould-Jacobs cyclization

Add time:09/26/2019    Source:sciencedirect.com

A Gould-Jacobs cyclization enabled the synthesis of several novel, so far undescribed 3,4,6-trisubstituted quinoline derivatives. They all bear substituents which are well-suited for further transformations, e.g. carboxylic acid or ester functions, halogens, terminal alkynes and hydroxyl groups. The synthesis of a highly active 3,4-disubstituted quinolin-6-yloxyacetamide fungicide gives proof of the manifold manipulations which are possible with these interesting heterobicyclic building blocks.

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