Original articleApplication of Huisgen (3 + 2) cycloaddition reaction: Synthesis of 1-(2,3-dihydrobenzofuran-2-yl-methyl [1,2,3]-triazoles and their antitubercular evaluations
-
Add time:09/10/2019 Source:sciencedirect.com
1,4-Disubstituted-1,2,3-triazoles (3–27) have been synthesized by [3+2] cycloaddition of different 2-(azidomethyl)-dihydronaptho(benzo)furans (2a, 2b, 2c and 2d) with different alkynes. All the compounds were screened for antitubercular activity against Mycobacterium tuberculosis H37Rv. Compounds 2a, 7, 9, 12 and 14 exhibited antitubercular activities with MIC ranging from 12.5 to 3.12 μg/ml.
We also recommend Trading Suppliers and Manufacturers of 1-Methyl-1,2,3-triazole (cas 16681-65-5). Pls Click Website Link as below: cas 16681-65-5 suppliers
Prev:Structures, molecular orbitals and UV–vis spectra investigations on methyl 1-benzyl-1H-1,2,3-triazole-4-carboxylate: A computational study
Next:Research paperSynthesis of new thiazolyl-pyrazolyl-1,2,3-triazole derivatives as potential antimicrobial agents) - 【Back】【Close 】【Print】【Add to favorite 】
- Related Information
- Research paperSynthesis of new thiazolyl-pyrazolyl-1,2,3-triazole derivatives as potential antimicrobial agents09/24/2019
- Structures, molecular orbitals and UV–vis spectra investigations on methyl 1-benzyl-1H-1,2,3-triazole-4-carboxylate: A computational study09/09/2019
- Discovery of 1,2,3-triazole-based fibroblast growth factor receptor modulators09/08/2019
- NoteThe first structural determination of a copper (II) complex containing the ligand [1-(4-((1H-benzo[d][1,2,3]triazol-2(3H)-yl)methyl)benzyl)-1H-benzo[d][1,2,3]triazole]09/07/2019
- A rapid synthesis of 2-substituted 1,2,3- triazole-1-oxide derivative starting from 4-(methyl)isonitrosoacetophenone and its Ni(II) complex: Characterization, DNA binding and cleavage properties09/06/2019
