A convenient synthesis of 5-fluorofuran-2-carboxylic acid

Add time:09/07/2019    Source:sciencedirect.com

A convenient synthesis of 5-fluorofuran-2-carboxylic acid has been achieved in two steps and 56% total yield. Fluorodenitration of commercially available benzyl 5-nitrofuran-2-carboxylate utilizing potassium fluoride and catalytic tetraphenylphosphonium bromide in sulfolane at 140 °C for 2 h furnished benzyl 5-fluorofuran-2-carboxylate. Hydrogenolysis of benzyl 5-fluorofuran-2-carboxylate gave the title compound.

We also recommend Trading Suppliers and Manufacturers of 5-NITROTHIOPHENE-2-CARBONITRILE (cas 16689-02-4). Pls Click Website Link as below: cas 16689-02-4 suppliers

Prev:A facile, scalable preparation of 4-oxo-4,7-dihydrothieno[2,3-b]pyridine-5-carbonitriles
Next:Inhibition of l-leucine methyl ester mediated killing of THP-1, a human monocytic cell line, by a new anti-inflammatory drug, T614)