Synthesis of 2-substituted 2H-chromenes using POTASSIUM VINYLTRIFLUOROBORATE (cas 13682-77-4)s

Add time:09/09/2019    Source:sciencedirect.com

2H-Chromenes were synthesized from salicylaldehyde using potassium vinylic borates in the presence of secondary amines. We synthesized these 2H-chromene derivatives as a part of an ongoing project to develop inhibitors for TGF-β receptors. Potassium vinyl trifluoroborates react with salicylaldehydes at 80 °C in the presence of a secondary amine and produced 2-substituted 2H-chromene derivatives with a 70–90% yield.

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