Collision induced dissociation of N-(pyridin-2-yl)-substituted benzo(thio)amides and N-(isoquinolin-1-yl)furan(thiophene)-2-carboxamides and their difluoroboranyl derivatives

Add time:07/15/2019    Source:sciencedirect.com

The effect of the properties of sulfur and oxygen atoms and of the presence/absence of the BF2 group on the collision induced dissociation (CID) behavior of singly charged ions generated by electrospray ionization (ESI) of N-(pyridin-2-yl)-substituted benzo(thio)amides and N-(isoquinolin-1-yl)furan(thiophene)-2-carboxamides and their difluoroboranyl derivatives has been investigated. The results show that O/S replacement (both in the amide/thioamide and the furan/thiophene moieties) has a strong influence on the CID fragmentation patterns. The loss of HOBF2 (or HSBF2) has been observed in ESI-CID MS/MS experiments performed for all difluoroboranyl derivatives. It can serve as a signature tag for the presence of the OBF2 (SBF2) moiety.

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