Synthesis of pyrrolophenanthridone alkaloid kalbretorine from indolecarboxylic acids via hypervalent iodine(III) mediated halodecarboxylation and reduction

Add time:09/07/2019    Source:sciencedirect.com

The treatment of 8,9,10-trimethoxy-7H-pyrrolo[3,2,1-de]phenanthridine-4,5-dicarboxylic acid with phenyliodine diacetate and potassium iodide in tetrahydrofuran gave the corresponding 4,5-diiodo derivative, which was converted to kalbretorine via reduction, demethylation, followed by alkylation.

We also recommend Trading Suppliers and Manufacturers of 4-Bromo-2-indolecarboxylic acid (cas 16732-64-2). Pls Click Website Link as below: cas 16732-64-2 suppliers

Prev:Research paperSynthesis and biological evaluation of N-substituted 3-oxo-1,2,3,4-tetrahydro-quinoxaline-6-carboxylic acid derivatives as tubulin polymerization inhibitors
Next:Conformation of the umifenovir cation in the molecular and crystal structures of four carboxylic acid salts)