Short communicationBiocatalytic functionalization of hydroxyalkyl acrylates and phenoxyethanol via phosphorylation

Add time:09/08/2019    Source:sciencedirect.com

The enzymatic phosphorylation of phenoxyethanol, 2-hydroxyethyl acrylate and 4-hydroxybutyl acrylate catalyzed by acid phosphatases PhoN-Sf and PiACP at the expense of inorganic di-, tri-, hexameta- or polyphosphate was applied to the preparative-scale synthesis of phosphorylated compounds. The reaction conditions were optimized with respect to enzyme immobilization, substrate concentration, pH and type of phosphate donor. The mild reaction conditions prevented undesired polymerization and hydrolysis of the acrylate ester moiety. Application of a continuous flow system allowed facile scale-up and mono-phosphates were obtained in up to 26% isolated yield with space-time yields of 0.89 kg L−1 h−1.

We also recommend Trading Suppliers and Manufacturers of (E)-methyl 3-(3-nitrophenyl)acrylate (cas 1664-59-1). Pls Click Website Link as below: cas 1664-59-1 suppliers

Prev:Radiation induced topotactic [2 + 2] dimerisation of acrylate derivatives among the layers of a CaFe layered double hydroxide followed by IR spectroscopy
Next:Photolithographically patternable nitrate-sensitive acrylate-based membrane)