Synthesis of [2.2]paracyclophane-based bidentate oxazoline–carbene ligands for the asymmetric 1,2-silylation of N-tosylaldimines

Add time:09/07/2019    Source:sciencedirect.com

A series of novel oxazoline-substituted imidazolium salts with planar and central chirality has been successfully synthesized and applied to copper-catalyzed enantioselective 1,2-silylation of N-tosylaldimines. The oxazoline–carbene copper complex generated in situ by the reaction of the oxazoline-substituted imidazolium and Cu2O demonstrated an exceptionally high catalytic activity in the asymmetric 1,2-silylation of N-tosylaldimines, affording chiral α-amino silanes with excellent yields and enantioselectivities.

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