Effects of 4,4′-dichloro-Diphenyl diselenide (cas 1666-13-3) (ClPhSe)2 on toxicity induced by mercuric chloride in mice: A comparative study with Diphenyl diselenide (cas 1666-13-3) (PhSe)2

Add time:09/25/2019    Source:sciencedirect.com

The effects of 4,4′-dichloro-Diphenyl diselenide (cas 1666-13-3) (ClPhSe)2 on the toxicity induced by mercuric chloride (HgCl2) were investigated and compared with diphenyl diselenide (PhSe)2. Mice received HgCl2 for three days and, on the third day, received (PhSe)2 or (ClPhSe)2. The results verified that the administration of (ClPhSe)2 in mice exposed to HgCl2 increased renal δ-aminolevulinate dehydratase (δ-ALA-D), Na+, K+-ATPase activities and non-protein thiol (NPSH) levels and also decreased thiobarbituric acid-reactive substances (TBARS) and ascorbic acid levels, when compared to mice exposed to HgCl2 + (PhSe)2. Plasma and urinary protein, hemoglobin and hematocrit levels and histological parameters were also ameliorated in mice exposed to HgCl2 + (ClPhSe)2. In addition, the hepatic damage in mice exposed to HgCl2 + (PhSe)2 was reduced in animals exposed to (ClPhSe)2. To sum up, the introduction of a functional group (chloro) in the aromatic ring of diaryl diselenide reduced the toxicity of this compound in liver and kidney of mice exposed to HgCl2.

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