An assessment of the clastogenic potential of 4-Chloromethylbiphenyl (cas 1667-11-4) in human lymphocytes in vitro
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Add time:09/26/2019 Source:sciencedirect.com
The clastogenic potential of 4CMB was assessed in vitro in human lymphocytes from 4 donors (2 male and 2 female) both with and without auxiliary metabolic activation. Although there were some variation in the response of the cells from different donors to 4CMB using 2 criteria for interpretation of the results; it was concluded that 4CMB was a clastogen, but only at dose levels that caused some cytotoxicity. The response was amplified by the inclusion of chromatid and chromosome gaps in the analysis of chromosome damage.
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