Effects of alprenolol, bunolol and propranolol on pulmonary resistance in the anaesthetized dog

Add time:09/09/2019    Source:sciencedirect.com

The β-receptor antagonists alprenolol, bunolol and propranolol were evaluated for their effects on pulmonary resistance in anaesthetized dogs in the absence and presence of bronchoconstrictor agents. The effectiveness of the β-receptor antagonists in (a) blocking isoprenaline-induced bronchodilatation in animals receiving histamine aerosol and (b) potentiating histamine-induced bronchoconstriction was also assessed. Propranolol, given in increasing doses to dogs not previously given bronchoconstrictor substances, caused an increase in pulmonary resistance; bunolol had no apparent effect and alprenolol decreased resistance. Propranolol and bunolol, given 30 min after a histamine aerosol challenge, increased resistance whereas alprenolol decreased resistance. Bronchospasm induced by histamine after the administration of the β-receptor antagonists was not significantly altered from control. Alprenolol had less effect on isoprenaline-induced bronchodilatation than did the other two agents. When administered at the peak of pilocarpine-induced bronchoconstriction, bunolol or propranolol produced significant increases in pulmonary resistance whereas alprenolol had no effect. The different effects of these selected β-receptor antagonists on pulmonary resistance suggest that the actions of propranolol are not representative of the pulmonary effects of this class of compounds.

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