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  • Photoreactive CMP-sialic acids as substrates for α2,6-sialyltransferase

  • Add time:09/25/2019    Source:sciencedirect.com

    Chemo-enzymatic synthesis afforded a series of CMP-activated sialic acids carrying a photoreactive group at C-9 or C-5, and in part a radiolabel as well. They were found to be accepted by α2,6-sialyltransferase. - Differing amino group reactivity of novel 5,9-diamino sialic acid enabled us to attach sequentially a benzophenone photophore at C-9 and a radiolabel at C-5.

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