Biosynthesis and disposition of γ-guanidinobutyric acid in mammalian tissues

Add time:09/08/2019    Source:sciencedirect.com

Transamidinase of kidney and pancreas was shown to catalyze the formation of γ-guanidinobutyric acid from γ-aminobutyric acid and arginine. The enzyme was also shown to be present in brain. Glycine was about ten times more active than γ-aminobutyric acid. A number of amino acids were tested for activity with purified hog kidney transamidinase. In addition to γ-aminobutyric acid, β-alanine, δ-aminovaleric, and lysine all had demonstrable activity.γ-Guanidinobutyric acid was found in all tissues of the rat. Following the intraperitoneal injection of γ-guanidinobutyric acid, no increase was observed in the brain concentration indicating that at least in brain, γ-guanidinobutyric acid arises mainly through synthesis and not as a result of dietary intake.

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