Resolution of (±)-2-AMINOHEPTANE (cas 123-82-0) enantiomers by inductive adsorption chromatography

Add time:09/08/2019    Source:sciencedirect.com

The use of inductive adsorption chromatography for enantiomer resolution involves a chiral additive to the mobile phase, the so-called inductive agent, which has the same chemical nature as the enantiomers to be resolved. In this way, (±)-2-aminoheptane enantiomers were partially resolved on a silica column by using (−)-α-methylbenzylamine as the mobile phase additive; the first-eluted fraction was composed of optically pure (−)-2-aminoheptane and represented up to 81% of the injected amount. The experimental conditions were varied in order to enhance the separation. Optically pure fractions were obtained at low loadings per unit cross-section and high capacity factors, but exceptions were observed. The inductive agent concentration has a large effect on retention, by displacement action, but not on the resolution.

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