The determination of 1,4-Dioxane (cas 123-91-1) in cosmetic products by gas chromatography with tandem mass spectrometry
-
Add time:09/10/2019 Source:sciencedirect.com
1,4-Dioxane (cas 123-91-1) is a potential human carcinogen and contaminant produced during the manufacturing process from specific cosmetic ingredients, such as certain detergents and emulsifiers. As such, 1,4-dioxane is not identified on product ingredient labels. To assess the concentration of 1,4-dioxane in cosmetic products, a gas chromatography-tandem mass spectrometry (GC–MS/MS) method using pulsed split injection and electron ionization was developed and validated. For liquid cosmetic products such as shampoo and lotion, test portions were extracted using fast ultrasound-assisted extraction (UAE) procedure without sample cleanup. For solid products (e.g. beauty bars), a C18 solid phase extraction (SPE) procedure was optimized to reduce potential interferences. The corresponding stable isotopically labeled analogue (1,4-dioxane-d8) was selected as an internal standard to compensate for matrix effects and sample recovery. Method recovery experiments were performed in lotion, oil gel, hair detangler, bubble bath and beauty bar (solid) sample matrices with recoveries of 84–108% and relative standard deviations less than 5% at three spike concentrations. Method limits of detection (LOD) and quantification (LOQ) for 1,4-dioxane were determined at 0.2 μg/g and 0.5 μg/g, respectively. The method was successfully used to determine 1,4-dioxane in 82 leave-on and rinse-off cosmetic products marketed toward children including bath products, hair treatment, lotions, beauty bars, washes, shampoos, and other products. 1,4-dioxane was detected in 47 of the 82 products with an average concentration of 1.54 μg/g (range: 0.23–15.3 μg/g). The method can increase sample throughput and reduce matrix-induced interferences.
We also recommend Trading Suppliers and Manufacturers of 1,4-Dioxane (cas 123-91-1). Pls Click Website Link as below: cas 123-91-1 suppliers
Prev:Stimulatory and inhibitory effects of metals on 1,4-Dioxane (cas 123-91-1) degradation by four different 1,4-Dioxane (cas 123-91-1)-degrading bacteria
Next:Simulation of in situ biodegradation of 1,4-Dioxane (cas 123-91-1) under metabolic and cometabolic conditions) - 【Back】【Close 】【Print】【Add to favorite 】
- Related Information
- Synergistic 1,4-Dioxane (cas 123-91-1) removal by non-thermal plasma followed by biodegradation09/29/2019
- Research paperPhotophysical study of an alkaloid harmaline in 1,4-Dioxane (cas 123-91-1)-water mixtures09/28/2019
- Clathrate hydrate formation of CO2 in the presence of water miscible (1,4-Dioxane (cas 123-91-1)) and partially water miscible (cyclopentane) organic compounds: Experimental measurement and thermodynamic modeling10/01/2019
- Removal of 1,4-Dioxane (cas 123-91-1) from landfill leachate by a rotating advanced oxidation contactor equipped with activated carbon/TiO2 composite sheets09/27/2019
- Review1,4-Dioxane (cas 123-91-1) as an emerging water contaminant: State of the science and evaluation of research needs09/26/2019
- Activation mechanism of peroxymonosulfate by biochar for catalytic degradation of 1,4-Dioxane (cas 123-91-1): Important role of biochar defect structures09/25/2019
- Simulation of in situ biodegradation of 1,4-Dioxane (cas 123-91-1) under metabolic and cometabolic conditions09/24/2019
- Stimulatory and inhibitory effects of metals on 1,4-Dioxane (cas 123-91-1) degradation by four different 1,4-Dioxane (cas 123-91-1)-degrading bacteria09/09/2019
- 1,4-Dioxane (cas 123-91-1) cosolvency impacts on trichloroethene dissolution and sorption☆09/08/2019